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The word substance originates from Latin substantia, literally meaning "standing under". The word was used to translate the Greek philosophical term ousia.

Substance may refer to:

• Substance theory, in philosophy, that element of an object without which it would not exist, or what exists only by itself (causa sui)
• Chemical substance, in chemistry, are material objects that can undergo various transformations related to artificial or natural phenomena
• Substance (rapper)
• Substance (Joy Division album)
• Substance (New Order album)
• Substance, a song by Haste The Day from the EP That They May Know You and redone for the album Burning Bridges
• Metal Gear Solid 2: Substance, a tactical espionage video game

See also:

• matter

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