Sargon the Sorcerer, comic superhero character from DC Comics, first appeared in 1941
Sargon, disembodied leader of a race of powerful aliens in the 1968 Star Trek episode "Return to Tomorrow"
Sargon, ruler of the Nine Worlds interplanetary empire in Robert Heinlein's 1957 science fiction novel Citizen of the Galaxy
Sargon, left-handed guitarist of the fictional band The Mesopotamians from the They Might Be Giants song on their 2007 album The Else
Sargon, leader of the fat men in Daniel Pinkwater's 1982 novel Slaves of Spiegel
Other uses
Sargon (chess), series of chess-playing software programs for personal computers
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