PRC or .prc may refer to:

• People's Republic of China, a country in East Asia
• Prince Royal's College, a private school in Chiang Mai, Thailand
• Permanent Resident Card, an type of identification card
• Communist Refoundation Party, an Italian reformed communist party
• Ernest A. Love Field (IATA code: PRC), a public airport near Prescott, Arizona
• Palestine Red Crescent Society, a humanitarian organization

• Peterborough Regional College
• Phase response curve showing biological responses to light and to exogenous melatonin in animals
• Physical Recreation Centre
• Popular Resistance Committees, various Palestinian militant organizations which operate in the Gaza Strip
• Portable Radio, Communication, an example is the AN/PRC-77 Portable Transceiver
• Postal Regulatory Commission, an independent regulatory agency
• Presbyterian Reformed Church
• Prestige class (PrC), in the Dungeons & Dragons role-playing game
• Producers Releasing Corporation, one of the larger Hollywood production conglomerates of Poverty Row of the late 30s-mid 40s
• Professional Regulation Commission, an agency of the government of the Republic of the Philippines
• Protestant Reformed Churches in America, a Protestant denomination of 27 churches and over 7,000 members
• Regionalist Party of Cantabria, the second oldest political party in the Spanish Autonomous Community of Cantabria
• Photosynthetic reaction center, the molecular unit responsible for absorbing light in photosynthesis

In computers:

• Volunteer computing or Public Resource Computing, a type of distributed computing
• Procfs, short for process file system:
• .prc (Palm OS), the file extension of executables for Palm OS and Mobipocket databases
• .prc (file format), a way to store 3D data in a PDF file

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